Astonishing 4-Year Survival in NSCLC With Pembro+Chemo

Astonishing 4-Year Survival in NSCLC With Pembro+Chemo

Lung cancer experts have been rejoicing over new longer-term results that continue to show the combination of immunotherapy and chemotherapy doubles survival compared with chemotherapy alone.The results are from a 4-year follow-up of 160 patients with previously untreated stage IV nonsmall cell lung cancer (NSCLC) taking part in the KEYNOTE-189 trial of immunotherapy with pembrolizumab (Keytruda, Merck) plus pemetrexed–platinum chemotherapy versus chemotherapy plus placebo.webmd.ads2.defineAd({id:’ads-pos-1122′,pos: 1122});After a median follow-up of 46.3 months, the median overall survival (OS) in the intention-to-treat population was 22.0 months with the combination versus 10.6 months with chemotherapy alone (hazard ratio [HR], 0.60).A similar pattern was seen for progression-free survival (PFS), with patients receiving the combination having a longer median PFS, at 9.0 months, versus 4.9 months with chemotherapy alone (HR, 0.50).

webmd.ads2.defineAd({id:’ads-pos-520′,pos: 520});”Stellar data” exclaimed Riyaz Shah, MD, PhD, consultant medical oncologist, Maidstone and Tunbridge Wells NHS Trust, UK, on Twitter.

webmd.ads2.defineAd({id:’ads-pos-1520′,pos: 1520});He described the results for the PD-L1 expression subgroups as “astonishing” and singled out the performance of the combination therapy in patients with very low (< 1%) tumor PD-L1 expression, showing more than 23% of patients were alive at 3 years versus just over 5% in the group given chemotherapy alone. Charu Aggarwal, MD, MPH, Leslye M. Heisler associate professor for lung cancer excellence, Penn Medicine, Philadelphia, said the outcomes with the combination of chemotherapy and immunotherapy were "terrific." webmd.ads2.defineAd({id:'ads-pos-141',pos: 141}); Sandip P. Patel, MD, medical oncologist, associate professor of medicine, UC San Diego Health, agreed that these long-term results were "very impressive." However, he noted the "full effect" of chemotherapy plus immunotherapy has not "fully been captured in our overall cancer mortality statistics in the US yet." webmd.ads2.defineAd({id:'ads-pos-420',pos: 420});The new results were presented January 28 at the 2020 World Conference on Lung Cancer, held virtually because of the ongoing pandemic.Previous results from KEYNOTE-189 had already demonstrated that, after a median follow-up of 10.5 months, adding pembrolizumab to chemotherapy significantly improves both OS and PFS compared with chemotherapy alone.The latest results show that the combination "continued to provide overall survival and progression-free survival benefit" in extended follow-up, said study presenter Jhanelle Elaine Gray, MD, chair, Department of Thoracic Oncology, Moffitt Cancer Center, Tampa, Florida.The 3-year OS rate with pembrolizumab plus chemotherapy compared with chemotherapy alone was 31.3% versus 17.4%, and estimated 3-year PFS was 11.8% versus 1.3%.Crucially, substantial improvements were even seen in patients with tumors with a low level of PD-L1 expression (measured as the PD-L1 tumor proportion score [TPS]). Gray highlighted the finding that the survival benefit with pembrolizumab plus chemotherapy was seen regardless of PD-L1 expression in the tumor, with a hazard ratio versus chemotherapy alone of 0.71 in patients with a TPS ≥ 50%, 0.66 in those with a TPS of 1%–49%, and 0.52 in patients with a TPS < 1%.A similar pattern was seen with PFS, with a hazard ratio of 0.36 in patients with a TPS ≥ 50%, 0.54 in those with a TPS of 1%–49%, and 0.68 in patients with a TPS < 1%.In addition, overall response rate and duration of response were also improved with combination therapy, regardless of tumor PD-L1 expression.Among 56 patients who completed 35 cycles of pembrolizumab, the objective response rate was 87.5% (with 10.7% having a complete response and 76.8% a partial response).At the data cutoff, 45 patients were alive, 28 did not have progressive disease, and seven had started a second course of pembrolizumab.The side effect profile of the combination was "manageable," Gray reported.The combination arm was associated with more grade 3-5 treatment-related adverse events than the chemotherapy alone arm, at 52.1% versus 42.1%, and more grade 3-5 immune-related adverse events and infusion reactions, at 27.7% versus 13.4%.Events leading to treatment discontinuation were also more common with pembrolizumab plus chemotherapy than chemotherapy, at 27.4% versus 9.9%.The combination of pembrolizumab plus pemetrexed–platinum has already become "a standard-of-care-therapy for patients with newly diagnosed metastatic nonsquamous NSCLC," Gray commented. The study was funded by MSD. Gray has reported receiving grant support and/or honoraria from Array, AstraZeneca, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Eli Lilly, Genentech, Merck, and institutional funding from MSD. 2020 World Conference on Lung Cancer Singapore. Abstract FP13.02. Presented January 28, 2021. For more from Medscape Oncology, join us on Twitter and Facebook. 33 12 Next Medscape Medical News © 2021 WebMD, LLC Send comments and news tips to news@medscape.net. Cite this: 'Astonishing' 4-Year Survival in NSCLC With Pembro+Chemo - Medscape - Feb 01, 2021. TOP PICKS FOR YOU webmd.ads2.defineAd({ id: 'ads-pos-904', pos: 904 }); webmd.ads2.defineAd({ id: 'ads-pos-906', pos: 906 }); webmd.ads2.defineAd({ id: 'ads-pos-907', pos: 907 });

Our Essay Writing Service Features

Qualified Writers
Looming deadline? Get your paper done in 6 hours or less. Message via chat and we'll get onto it.
Anonymity
We care about the privacy of our clients and will never share your personal information with any third parties or persons.
Free Turnitin Report
A plagiarism report from Turnitin can be attached to your order to ensure your paper's originality.
Safe Payments
The further the deadline or the more pages you order, the lower the price! Affordability is in our DNA.
No Hidden Charges
We offer the lowest prices per page in the industry, with an average of $7 per page
24/7/365 Support
You can contact us any time of day and night with any questions; we'll always be happy to help you out.
$15.99 Plagiarism report
$15.99 Plagiarism report
$15.99 Plagiarism report
$15.99 Plagiarism report
$3.99 Outline
$21.99 Unlimited Revisions
Get all these features for $65.77 FREE
Do My Paper

Frequently Asked Questions About Our Essay Writing Service

Academic Paper Writing Service

Our essay writers will gladly help you with:

Essay
Business Plan
Presentation or Speech
Admission Essay
Case Study
Reflective Writing
Annotated Bibliography
Creative Writing
Report
Term Paper
Article Review
Critical Thinking / Review
Research Paper
Thesis / Dissertation
Book / Movie Review
Book Reviews
Literature Review
Research Proposal
Editing and proofreading
Other
Find Your Writer

Latest Feedback From Our Customers

Customer ID:  # 678224
Research Paper
Highly knowledgeable expert, reasonable price. Great at explaining hard concerts!
Writer: Raymond B.
08/10/2021
Customer ID: # 619634
Essay (any type)
Helped me with bear and bull markets right before my exam! Fast teacher. Would work with Grace again.
Writer: Lilian G.
08/10/2021
Customer ID: # 519731
Research Paper
If you are scanning reviews trying to find a great tutoring service, then scan no more. This service elite!
Writer: Grace P.
08/10/2021
Customer ID: #499222
Essay (any type)
This writer is great, finished very fast and the essay was perfect. Writer goes out of her way to meet your assignment needs!
Writer: Amanda B.
08/10/2021
Place an Order

Calculate the price of your order

You will get a personal manager and a discount.
We'll send you the first draft for approval by at
Total price:
$0.00
×

Powered by WhatsApp Chat

× How can I help you?