Pathophysiology And Physiology Of Pain

Pathophysiology And Physiology Of Pain

Free Samples

Pathophysiology And Physiology Of Pain

.cms-body-content table{width:100%!important;} #subhidecontent{ position: relative;
overflow-x: auto;
width: 100%;}

Pathophysiology And Physiology Of Pain

0 Download3 Pages / 699 Words

Discuss about the Pathophysiology and Physiology of Pain.

Physiology of low back pain
Nociception is generated when the electrical impulse enter the dorsal root ganglion via dendrite fibre. The impulse is then accrued by the axon to the spinal cord. Nocireceptors are responsible for transmitting impulse from site of injury as body’s physiologic response to the central nervous system. Sue feels the pain radiating in lower back as it travels from injured tissues to thalamocoticol neurons (Anwar, 2016). Thus, neurons connect both spinal cord and brain, through the process of transduction, conduction, and transmission. Upon nociception, spinal modeulation may have occurred in Sue as the electrical signals are relayed to the brain centres. Sue feels the pain in her lower back when the brain (CNS) interprets the signals and generates the supraspinal responses (Craft et al., 2015, pp.137-153). As per, the clinical examination, Sue’s L3 to L4 spinal segment, positioned in the middle of the lumbar spine, was found with tenderness and central protrusions. Injury may have occurred due to repeated movements of neck and shoulder muscles in fire rescue services and lifting heavy weights. There might be unwanted contact between nerve and the disc, causing herniated disc and sequentially pain (Parker et al., 2015).  The protrusions and tenderness in Sue’s lumbar spine may be due to wear and tear of the disc, which is a degenerative cascade. The pain may also have caused by the enlargement of the facet joints of the segment leading to stenosis. Fire rescue service involves strenuous activity causing compression of spinal nerve roots and sequentially degeneration (Tobert & Harris, 2018).
Pharmacological actions and effects of NSAIDS
NSAIDS are administered depending on degree of swelling, stiffness, tenderness or pain in the area of injury, which means in dose dependent manner. Upon administration of NSAIDS, Sue may experience decrease in back pain as well as inflammation and consequently stiffness. The NSADIS inhibits the Cyclooxygenase (COX), pathway and decreases pain. Central to it is Arachdoinic acid that exhibits the inflammatory effect (Bryant & Knights, 2014, pp. 319 – 339). Sequentially, the synthesis of prostaglandin and eicosanoids are inhibited. COX2 increases the production of Prostanoid during inflammation through cytokines and the normal cellular process is maintained by COX1. Both play their role in inflammation, swelling and pain. The use of NSAIDS, for Sue will help reduce the lower back pain as they exhibit anti-inflammatory effect. Prostaglandins are primary agents in nocicpetion and inflammation. NSAIDS like ibuprofen, Naxpoxen, aspirin, help reduce the back and neck pain through anti-inflammatory effect (Sandilands & Bateman, 2016).
The use of   NSAIDS involves complications depending on the dose and the drug used. US FDA recommends lowest effective dose, as long as required, due to its higher efficacy (Schilling, 2016). Different drugs vary in their toxicity level and therapeutic effects. Side effects are usually manifested as, allergies, stomach ulcers, liver or kidney damage. In case Sue liver damage may occur as she consumes alcohol. It may occur with administration of acetaminophen and can be avoided if taken for short duration. Long term use of NSAIDS is associated with greater side effects (Sandilands & Bateman, 2016).
Anwar, K. (2016). Pathophysiology of pain. Disease-a-Month: DM, 62(9), 324-329. Doi: 10.1016/j.disamonth.2016.05.015
Bryant, B., & Knights, K. (2015). Pharmacology for health professionals (4th Ed.). Chatswood, N.S.W: Elsevier
Craft, J., Gordon, C., Huether, S. E., McCance, K. L., & Brashers, V. L. (2015). Understanding pathophysiology-ANZ adaptation. Elsevier Health Sciences. ISBN : 9780729541602
Parker, S. L., Mendenhall, S. K., Godil, S. S., Sivasubramanian, P., Cahill, K., Ziewacz, J., & McGirt, M. J. (2015). Incidence of low back pain after lumbar discectomy for herniated disc and its effect on patient-reported outcomes. Clinical Orthopaedics and Related Research®, 473(6), 1988-1999. DOI:
Sandilands, E. A., & Bateman, D. N. (2016). Non-steroidal anti-inflammatory drugs. Medicine, 44(3), 185-186. DOI:
Schilling, R. (2016). Pain Treatment. Pain. Retrieved from:
Tobert, D. G., & Harris, M. B. (2018). Degenerative Lumbar Spinal Stenosis and Spondylolisthesis. In Principles of Orthopedic Practice for Primary Care Providers (pp. 47-59). Springer, Cham. DOI:

Free Membership to World’s Largest Sample Bank

To View this & another 50000+ free samples. Please put
your valid email id.


Yes, alert me for offers and important updates


Download Sample Now

Earn back the money you have spent on the downloaded sample by uploading a unique assignment/study material/research material you have. After we assess the authenticity of the uploaded content, you will get 100% money back in your wallet within 7 days.

UploadUnique Document

DocumentUnder Evaluation

Get Moneyinto Your Wallet

Total 3 pages


*The content must not be available online or in our existing Database to qualify as

Cite This Work
To export a reference to this article please select a referencing stye below:


My Assignment Help. (2019). Pathophysiology And Physiology Of Pain. Retrieved from

“Pathophysiology And Physiology Of Pain.” My Assignment Help, 2019,

My Assignment Help (2019) Pathophysiology And Physiology Of Pain [Online]. Available from:[Accessed 18 December 2021].

My Assignment Help. ‘Pathophysiology And Physiology Of Pain’ (My Assignment Help, 2019) accessed 18 December 2021.

My Assignment Help. Pathophysiology And Physiology Of Pain [Internet]. My Assignment Help. 2019 [cited 18 December 2021]. Available from:

.close{position: absolute;right: 5px;z-index: 999;opacity: 1;color: #ff8b00;}


Thank you for your interest
The respective sample has been mail to your register email id


$20 Credited
successfully in your wallet.
* $5 to be used on order value more than $50. Valid for
only 1

Account created successfully!
We have sent login details on your registered email.



Are you feeling frustated running over assignment writing services who commit something and deliver other? Are you tired os pending huge on getting simple help for your solve my assignment problems? Well, we do not say that you should hire us but of course, you should give us a try. We know you will never look anywhere else after that. This is because we have one of the fastest turnaround time in the industry, a team of 5000+ phd experts, a strong editorial team and an ever responding student support team. Know what quality assignment means just by joining us.

Latest Healthcare Samples

div#loaddata .card img {max-width: 100%;

5N1794 Safety And Health At Work
Download :
0 | Pages :

Course Code: 5N1794
University: University College Cork is not sponsored or endorsed by this college or university

Country: Ireland

Assignment 1
Answer to question 1
I have conducted a survey at my workplace maned Lady’s Hospice and Care Services to observe the working environment. The aim of the survey is to find if it is a safe, healthy, secured and fulfilling place to work. A visual survey was conducted to locate and record the safety signs in the workplace. The objective of the survey is to observe and list different types of signs, location, their prom…
Australia Maple Ridge Management Introduction to film studies University of New South Wales Masters in Business Administration 

400837 Health And Socio Political Issues In Aged Care
Download :
0 | Pages :

Course Code: 400837
University: Western Sydney University is not sponsored or endorsed by this college or university

Country: Australia

Palliative care services are designed to improve the life of patient with progressive disease. People receiving palliative care have illness that has no prospect of cure.  As per the World Health Organisation, palliative care is a care given to patient suffering from life threatening illness to improve their quality of life by preventing and providing relief from sufferings by early recognition , assessment and trea…
Australia Minchinbury Management University of New South Wales 

PUBH6304 Global Health
Download :
0 | Pages :

Course Code: PUBH6304
University: The University Of Newcastle is not sponsored or endorsed by this college or university

Country: Australia

Human Immunodeficiency Virus Infection and Acquired Immune Deficiency Syndrome (HIV/AIDS) is the spectrum of medical conditions caused due to human immunodeficiency virus (HIV) following which the patient suffers from a series medical complications due to suppression of the immune system of the body. With the progression of the disease, the patient is likely to suffer from a wide range of infections like tuberculosis and other opportu…
United States Newark Management University of New York Masters in Business Administration 

CON 321 Health Related Research
Download :
0 | Pages :

Course Code: CON321
University: University Of Southern Maine is not sponsored or endorsed by this college or university

Country: United States

Leadership in the hospital is the ability to influence the staff toward providing quality health care. Leadership involves influencing human behavior to create a positive working environment (Langlois, 2012). Good leadership enables healthy relationships among staffs in the hospital enhancing quality delivery of health care services. Leadership is responsible to building teams that have trust, respect, support and effecti…

BL9412 Public Health
Download :
0 | Pages :

Course Code: BL9412
University: University Of The West Of England is not sponsored or endorsed by this college or university

Country: United Kingdom

According to the researchers, it can be said that the management of the health care organizations has become a difficult task nowadays and the reason behind this is the occurrence of various issues in this sector (Hall et al., 2014). Therefore, the administrative employees of the organization should incorporate various revolutionized strategies for enriching the worth of care provided by the hospital to its clients and re…
Australia Ryde Management Information system strategy University of New South Wales (UNSW) Masters in Business Administration 


Our Essay Writing Service Features

Qualified Writers
Looming deadline? Get your paper done in 6 hours or less. Message via chat and we'll get onto it.
We care about the privacy of our clients and will never share your personal information with any third parties or persons.
Free Turnitin Report
A plagiarism report from Turnitin can be attached to your order to ensure your paper's originality.
Safe Payments
The further the deadline or the more pages you order, the lower the price! Affordability is in our DNA.
No Hidden Charges
We offer the lowest prices per page in the industry, with an average of $7 per page
24/7/365 Support
You can contact us any time of day and night with any questions; we'll always be happy to help you out.
$15.99 Plagiarism report
$15.99 Plagiarism report
$15.99 Plagiarism report
$15.99 Plagiarism report
$3.99 Outline
$21.99 Unlimited Revisions
Get all these features for $65.77 FREE
Do My Paper

Frequently Asked Questions About Our Essay Writing Service

Academic Paper Writing Service

Our essay writers will gladly help you with:

Business Plan
Presentation or Speech
Admission Essay
Case Study
Reflective Writing
Annotated Bibliography
Creative Writing
Term Paper
Article Review
Critical Thinking / Review
Research Paper
Thesis / Dissertation
Book / Movie Review
Book Reviews
Literature Review
Research Proposal
Editing and proofreading
Find Your Writer

Latest Feedback From Our Customers

Customer ID:  # 678224
Research Paper
Highly knowledgeable expert, reasonable price. Great at explaining hard concerts!
Writer: Raymond B.
Customer ID: # 619634
Essay (any type)
Helped me with bear and bull markets right before my exam! Fast teacher. Would work with Grace again.
Writer: Lilian G.
Customer ID: # 519731
Research Paper
If you are scanning reviews trying to find a great tutoring service, then scan no more. This service elite!
Writer: Grace P.
Customer ID: #499222
Essay (any type)
This writer is great, finished very fast and the essay was perfect. Writer goes out of her way to meet your assignment needs!
Writer: Amanda B.
Place an Order

Calculate the price of your order

You will get a personal manager and a discount.
We'll send you the first draft for approval by at
Total price:

Powered by WhatsApp Chat

× How can I help you?